Coping with Uncertainty in Everyday Situations (CUES)

Coping with Uncertainty in Everyday Situations (CUES) focused on the development of an intervention package to address anxiety relating to uncertainty experienced by autistic children. For children and young people with autism spectrum disorder (ASD), anxiety can be a significant problem. Some advances have been made recently in the development of interventions to tackle anxiety in ASD but these interventions are often simply practical adaptations of programmes designed for children without ASD that have been altered to make them more accessible, rather than based on theoretically driven frameworks of why children with ASD might be more vulnerable to anxiety. Over the past few years we have developed an evidence base for the importance of a thinking style which involves ‘intolerance of uncertainty’ to the onset and continuation of anxiety in children with ASD. Based on this theory, with the funding from the Children’s Foundation, we have developed an intervention package that focuses on addressing intolerance of uncertainty in children with ASD (Coping with Uncertainty in Everyday Situations CUES ©). Our study involved the development of a parent-based programme of intervention based on CBT principles, focusing specifically on intolerance of uncertainty for young people with ASD experiencing anxiety. The intervention involves parents attending eight, weekly two hour sessions alongside other parents and provides parents with strategies and tools to assist their child help to develop a more flexible approach to uncertainty and therefore reduce IU related anxiety. Our study has enabled us to develop and provide preliminary evaluation of the acceptability of our novel intervention for parents of children with ASD.

Want to participate in a study?

 “Hi I'm Dr Samuel Chawner from Cardiff University in the UK and we're looking for volunteers for research into 15q11.2 deletions and 15q11.2 duplications.

We are interested in assessing the behaviour and psychological and intellectual functioning of individual who have been diagnosed with 15q11.2 deletion or duplication who are aged 6 and older. If you choose to take part, you will be visited by two people from our research team in your home at a time most convenient for you. 

If you are interested to find out more about our research please email us: “.


Additional Reading material can be found by clicking on the link below.





stronger together.


Burnside-Butler working with families affected by 15q11.2 bp1 to bp2

Posted in one of the Facebook forums, so I thought I’d share.....

Please see this. Dr. Butler is studying parents and children with the microdeletion. He is doing a research on 15q11.2 trying to find more about our microdeletion. Please contact him.

"We are interested in learning more about the genetic and clinical aspects of 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome which is now recognized as one of the most common causes of speech, learning and behavior problems in children based on recent genetic testing results. If you would like to learn more about participating in our research, please call 913-588-1800.



Merlin G. Butler, MD, PhD

University of Kansas Medical Center

Kansas City, Kansas 66160"